生物活性
Bortezomib (Velcade)是26S蛋白酶体的高度选择性，可逆抑制剂。
靶点信息
| 20S proteasome (Cell-free assay) | | | | |
| 0.6 nM(Ki) | | | | |
化学数据
| 目录号 | A10160 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 384.2 |
| Formula | C19H25BN4O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 179324-69-7 |
| Synonyms | MG-341, PS-341 |
| SMILES | B([C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O |
溶解度
| In vitro (25°C) | DMSO | 66 mg/mL (171.77 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 2% DMSO+30% PEG 300+ddH2O | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 26.03 mL | 130.14 mL | 260.28 mL |
| 0.5 mM | 5.21 mL | 26.03 mL | 52.06 mL |
| 1 mM | 2.6 mL | 13.01 mL | 26.03 mL |
| 5 mM | 0.52 mL | 2.6 mL | 5.21 mL |
*The above data is based on the productmolecular weight 384.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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