生物活性
Bosutinib (SKI-606)是一种酪氨酸激酶抑制剂。
靶点信息
| Abl (Cell-free assay) | Src (Cell-free assay) | | | |
| 1 nM | 1.2 nM | | | |
化学数据
| 目录号 | A10161 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 530.4 |
| Formula | C26H29Cl2N5O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 380843-75-4 |
| Synonyms | SKI-606, SKI606 |
| SMILES | CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC |
溶解度
| In vitro (25°C) | DMSO | 93 mg/mL (175.31 mM) |
| Water | Insoluble |
| Ethanol | 2 mg/mL (3.77 mM) |
| In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 9 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 18.85 mL | 94.27 mL | 188.54 mL |
| 0.5 mM | 3.77 mL | 18.85 mL | 37.71 mL |
| 1 mM | 1.89 mL | 9.43 mL | 18.85 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.77 mL |
*The above data is based on the productmolecular weight 530.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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