生物活性
Celecoxib是一种磺胺类非甾体抗炎药（NSAID）和选择性COX-2抑制剂，在Sf9细胞中IC50为40 nM。
靶点信息
化学数据
| 目录号 | A10193 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 381.4 |
| Formula | C17H14F3N3O2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 169590-42-5 |
| Synonyms | Celebrex, Celebra |
| SMILES | CC1=CC=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F |
溶解度
| In vitro (25°C) | DMSO | 65 mg/mL (170.44 mM) |
| Water | Insoluble |
| Ethanol | 28 mg/mL (73.42 mM) |
| In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 26.22 mL | 131.1 mL | 262.19 mL |
| 0.5 mM | 5.24 mL | 26.22 mL | 52.44 mL |
| 1 mM | 2.62 mL | 13.11 mL | 26.22 mL |
| 5 mM | 0.52 mL | 2.62 mL | 5.24 mL |
*The above data is based on the productmolecular weight 381.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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