生物活性
Cerubidine (Daunorubicin HCl,Rubidomycin HCl)通过插入和抑制大分子生物合成与DNA相互作用。这抑制了拓扑异构酶II的进程，该酶使DNA中的超螺旋松弛以进行转录。
靶点信息
| DNA synthesis (Cell-free assay) | | | | |
| 20 nM(Ki) | | | | |
化学数据
| 目录号 | A10194 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 564.0 |
| Formula | C27H29NO10.HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 23541-50-6 |
| Synonyms | Daunorubicin HCl, Rubidomycin HCl |
| SMILES | C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)C)O)N)O.Cl |
溶解度
| In vitro (25°C) | DMSO | 93 mg/mL (164.9 mM) |
| Water | 93 mg/mL (164.9 mM) |
| Ethanol | Insoluble |
| In vivo | Saline | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 17.73 mL | 88.65 mL | 177.3 mL |
| 0.5 mM | 3.55 mL | 17.73 mL | 35.46 mL |
| 1 mM | 1.77 mL | 8.87 mL | 17.73 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.55 mL |
*The above data is based on the productmolecular weight 564.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
m.cnreagent.com