生物活性
PD184352 (CI-1040)是一种ATP非竞争性MEK1/2抑制剂，在基于细胞的测定中，IC50为17 nM，对MEK1/2的选择性是对MEK5的100倍。
靶点信息
| MEK1 (Cell-free assay) | MEK2 (Cell-free assay) | | | |
| 17 nM | 17 nM | | | |
化学数据
| 目录号 | A10212 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 478.7 |
| Formula | C17H14ClF2IN2O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 212631-79-3 |
| Synonyms | CI-1040 |
| SMILES | C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl |
溶解度
| In vitro (25°C) | DMSO | 92 mg/mL (192.19 mM) |
| Water | Insoluble |
| Ethanol | 13 mg/mL (27.15 mM) |
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol, pH 9 | 9 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 20.89 mL | 104.45 mL | 208.9 mL |
| 0.5 mM | 4.18 mL | 20.89 mL | 41.78 mL |
| 1 mM | 2.09 mL | 10.44 mL | 20.89 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.18 mL |
*The above data is based on the productmolecular weight 478.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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