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CP-690550(Tofacitinib citrate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CP-690550(Tofacitinib citrate)图片
CAS NO:540737-29-9
包装与价格：
包装价格(元)
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
CP690550, tasocitinib citrate, CP-690,550
产品介绍

生物活性

CP-690550 (Tofacitinib citrate)是口服的高选择性Janus激酶（JAK）酶抑制剂。

Targets

TargetValue
JAK3IC50: 1nM
JAK2IC50: 20nM
JAK1IC50: 112nM
ROCK2IC50: 3.4μM
LCKIC50: 3.87μM
IRKIC50: >10μM
CDK2IC50: >10μM
CDK5IC50: >10μM
EGFRIC50: >10μM
MAPK2/ERK2IC50: >10μM
JNK1/SAPK1cIC50: >10μM
SAPK2a/p38IC50: >10μM
SAPK2b/p38b2IC50: >10μM
SAPK3/p38gIC50: >10μM
SAPK4/p38dIC50: >10μM
MAPKAPK2IC50: >10μM
MAPKAP-K1bIC50: >10μM
MSK1IC50: >10μM
PRAKIC50: >10μM
PKAIC50: >10μM
PKCαIC50: >10μM
PDK-1IC50: >10μM
PKBαIC50: >10μM
SGKIC50: >10μM
p70S6KIC50: >10μM
GSK-3βIC50: >10μM
AMPKIC50: >10μM
Chk1IC50: >10μM
CK2IC50: >10μM
PHKIC50: >10μM
CSKIC50: >10μM
CDK2/CyclinAIC50: >10μM
PI3KIC50: >10μM

化学数据

目录号A10241
作用机制Inhibitor (抑制剂)
M. Wt504.5
FormulaC16H20N6O.C6H8O7
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.540737-29-9
SynonymsCP690550, tasocitinib citrate, CP-690,550
SMILESC[C@@H]1CCN(C[C@@H]1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

溶解度

In vitro (25°C)DMSOWarmed: 94 mg/mL (186.32 mM)
WaterInsoluble
EthanolInsoluble
In vivo0.5% methylcellulose28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM19.82 mL99.11 mL198.22 mL
0.5 mM3.96 mL19.82 mL39.64 mL
1 mM1.98 mL9.91 mL19.82 mL
5 mM0.4 mL1.98 mL3.96 mL

*The above data is based on the productmolecular weight 504.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.