生物活性
Cyclosporin A (Cyclosporine A)是一种免疫抑制剂，广泛用于异体后器官移植，以降低免疫系统的活性。
靶点信息
| calcineurin (Cell-free assay) | | | | |
| 7 nM | | | | |
化学数据
| 目录号 | A10260 |
| M. Wt | 1202.6 |
| Formula | C62H111N11O12 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 59865-13-3 |
| Synonyms | Ciclosporin A, CsA, Ciclosporin, cyclosporine, cyclosporin, |
| SMILES | CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C |
溶解度
| In vitro (25°C) | DMSO | Warmed: 99 mg/mL (82.32 mM) |
| Water | Insoluble |
| Ethanol | Warmed: 99 mg/mL (82.32 mM) |
| In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 8.32 mL | 41.58 mL | 83.15 mL |
| 0.5 mM | 1.66 mL | 8.32 mL | 16.63 mL |
| 1 mM | 0.83 mL | 4.16 mL | 8.32 mL |
| 5 mM | 0.17 mL | 0.83 mL | 1.66 mL |
*The above data is based on the productmolecular weight 1202.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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