Extracted?from?Glycyrrhiza inflata Batalin;Store?the?product?in?sealed,?cool?and?dry?condition
CAS：144506-14-9
分子式：C21H22O4
分子量：338.15
纯度：98%
存储：Store at -20°C

Background:

Licochalcone C could inhibit α-glucosidase, with IC50s of<100 nM and 92.43 μM for α-glucosidase and protein tyrosine phosphatase 1B (PTP1B), respectively.

Licochalcone C could inhibit α- glucosidase, with IC50s of<100 nM and 92.43 μM for α- glucosidase and PTP1B, respectively[1]. It is also indicated that Licochalcone C induces T24 cell apoptosis in a concentration?dependent manner. Licochalcone C treatment reduces the levels of the anti?apoptotic mRNAs (Bcl-2, Bcl-w and Bcl-XL) and increases expression of the pro-apoptotic mRNAs (Bax and Bim). The Bcl-2 family inhibitor (ABT-737) reduces apoptosis induced by licochalcone C in T24 cells[2].

参考文献:
[1]. Zhenghong Guo, et al. Chemical profile and inhibition of α-glycosidase and protein tyrosine phosphatase 1B (PTP1B) activities by flavonoids from licorice (Glycyrrhiza uralensis Fisch). journal of functional foods 14 ( 2015 ) 324-336.
[2]. PENGLONG WANG, et al. Licochalcone C induces apoptosis via B-cell lymphoma 2 family proteins in T24 cells. Mol Med Rep. 2015 Nov;12(5):7623-8.