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Dapagliflozin(BMS512148)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dapagliflozin(BMS512148)图片
CAS NO:461432-26-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
BMS512148, BMS-512148
产品介绍

生物活性

Dapagliflozin (BMS512148)抑制钠-葡萄糖转运蛋白(SGLT2)的亚型2,后者负责肾脏中至少90%的葡萄糖重吸收。

化学数据

目录号A10285
作用机制Inhibitor (抑制剂)
M. Wt408.9
FormulaC21H25ClO6
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.461432-26-8
SynonymsBMS512148, BMS-512148
SMILESCCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)Cl

溶解度

In vitro (25°C)DMSO75 mg/mL (183.43 mM)
WaterInsoluble
Ethanol15 mg/mL (36.68 mM)
In vivo5% DMSO+40%PEG300+5% tween80+50% H2O3.8 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM24.46 mL122.28 mL244.56 mL
0.5 mM4.89 mL24.46 mL48.91 mL
1 mM2.45 mL12.23 mL24.46 mL
5 mM0.49 mL2.45 mL4.89 mL

*The above data is based on the productmolecular weight 408.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.