生物活性
Dapagliflozin (BMS512148)抑制钠-葡萄糖转运蛋白(SGLT2)的亚型2,后者负责肾脏中至少90%的葡萄糖重吸收。
化学数据
目录号 | A10285 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 408.9 |
Formula | C21H25ClO6 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 461432-26-8 |
Synonyms | BMS512148, BMS-512148 |
SMILES | CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)Cl |
溶解度
In vitro (25°C) | DMSO | 75 mg/mL (183.43 mM) |
Water | Insoluble |
Ethanol | 15 mg/mL (36.68 mM) |
In vivo | 5% DMSO+40%PEG300+5% tween80+50% H2O | 3.8 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 24.46 mL | 122.28 mL | 244.56 mL |
0.5 mM | 4.89 mL | 24.46 mL | 48.91 mL |
1 mM | 2.45 mL | 12.23 mL | 24.46 mL |
5 mM | 0.49 mL | 2.45 mL | 4.89 mL |
*The above data is based on the productmolecular weight 408.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.