生物活性
DAPT (GSI-IX)是一种γ-分泌酶抑制剂，可导致人原代神经元培养物中Aβ40和Aβ42水平降低，总Aβ和Aβ42的IC50值分别为115和200 nM。
靶点信息
| Aβ (HEK 293 cells) | γ secretase(Aβ) (HEK 293 cells) | | | |
| 20 nM | 20 nM | | | |
化学数据
| 目录号 | A10288 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 432.5 |
| Formula | C23H26F2N2O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 208255-80-5 |
| Synonyms | GSIIX |
| SMILES | C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F |
溶解度
| In vitro (25°C) | DMSO | 79 mg/mL (182.67 mM) |
| Water | Insoluble |
| Ethanol | 46 mg/mL (106.36 mM) |
| In vivo | 4% DMSO+corn oil | 9 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 23.12 mL | 115.61 mL | 231.21 mL |
| 0.5 mM | 4.62 mL | 23.12 mL | 46.24 mL |
| 1 mM | 2.31 mL | 11.56 mL | 23.12 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.62 mL |
*The above data is based on the productmolecular weight 432.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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