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Dasatinib(BMS-354825)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dasatinib(BMS-354825)图片
CAS NO:302962-49-8
包装与价格:
包装价格(元)
100mg电议
200mg电议
10mM * 1mL in DMSO电议

产品名称
Sprycel
产品介绍

生物活性

Dasatinib (BMS-354825)是一种口服多BCR/ABL和Src家族酪氨酸激酶抑制剂。Dasatinib (BMS-354825)的主要靶标是BCR/ABL,Src,c-Kit,ephrin受体和其他几种酪氨酸激酶,但不是erbB激酶,例如EGFR或Her2。

靶点信息

Abl (Cell-free assay)Src (Cell-free assay)c-Kit (D816V) (Cell-free assay)c-Kit (wt) (Cell-free assay)
0.6 nM0.8 nM37 nM79 nM

化学数据

目录号A10290
作用机制Inhibitor (抑制剂)
M. Wt488.0
FormulaC22H26ClN7O2S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.302962-49-8
SynonymsSprycel
SMILESCC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C

溶解度

In vitro (25°C)DMSO84 mg/mL (172.12 mM)
WaterInsoluble
EthanolInsoluble
In vivo4% DMSO+30% PEG 300+5% Tween 80+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM20.49 mL102.46 mL204.92 mL
0.5 mM4.1 mL20.49 mL40.98 mL
1 mM2.05 mL10.25 mL20.49 mL
5 mM0.41 mL2.05 mL4.1 mL

*The above data is based on the productmolecular weight 488.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.