生物活性
Droxinostat是HDAC3，HDAC6和HDAC8的选择性抑制剂，显示出可比较的HDAC6和HDAC8抑制作用，IC50分别为2.47和1.46μmol/ L。
Targets
| Target | Value |
| HDAC8 | IC50: 1.46μM |
| HDAC6 | IC50: 2.47μM |
| HDAC3 | IC50: 16.9μM |
| HDAC9 | IC50: >20μM |
| HDAC10 | IC50: >20μM |
| HDAC1 | IC50: >20μM |
| HDAC2 | IC50: >20μM |
| HDAC4 | IC50: >20μM |
| HDAC5 | IC50: >20μM |
| HDAC7 | IC50: >20μM |
化学数据
| 目录号 | A10337 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 243.7 |
| Formula | C11H14ClNO3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 99873-43-5 |
| SMILES | CC1=C(C=CC(=C1)Cl)OCCCC(=O)NO |
溶解度
| In vitro (25°C) | DMSO | 47 mg/mL (192.86 mM) |
| Water | Insoluble |
| Ethanol | 47 mg/mL (192.86 mM) |
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 41.03 mL | 205.17 mL | 410.34 mL |
| 0.5 mM | 8.21 mL | 41.03 mL | 82.07 mL |
| 1 mM | 4.1 mL | 20.52 mL | 41.03 mL |
| 5 mM | 0.82 mL | 4.1 mL | 8.21 mL |
*The above data is based on the productmolecular weight 243.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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