生物活性
LY317615（Enzastaurin）是一种有效的，选择性的PKCβ抑制剂，具有抗增殖活性（IC50 =?6 nM）。
靶点信息
| PKCβ (Cell-free assay) | PKCα (Cell-free assay) | PKCγ (Cell-free assay) | PKCε (Cell-free assay) | |
| 6 nM | 39 nM | 83 nM | 110 nM | |
化学数据
| 目录号 | A10356 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 515.6 |
| Formula | C32H29N5O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 170364-57-5 |
| Synonyms | LY-317615 |
| SMILES | CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)C6CCN(CC6)CC7=CC=CC=N7 |
溶解度
| In vitro (25°C) | DMSO | 29 mg/mL (56.24 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 15% Captisol | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 19.39 mL | 96.97 mL | 193.95 mL |
| 0.5 mM | 3.88 mL | 19.39 mL | 38.79 mL |
| 1 mM | 1.94 mL | 9.7 mL | 19.39 mL |
| 5 mM | 0.39 mL | 1.94 mL | 3.88 mL |
*The above data is based on the productmolecular weight 515.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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