生物活性
Everolimus (RAD001)是西罗莫司的40-O-(2-羟乙基)衍生物，与西罗莫司作为mTOR抑制剂的作用相似。
靶点信息
| mTOR (FKBP12) (Cell-free assay) | | | | |
| 1.6 nM-2.4 nM | | | | |
化学数据
| 目录号 | A10374 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 958.2 |
| Formula | C53H83NO14 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 159351-69-6 |
| Synonyms | SDZ-RAD, Certican, Zortress, Afinitor |
| SMILES | C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OCCO)C)/C)O)OC)C)C)/C)OC |
溶解度
| In vitro (25°C) | DMSO | 91 mg/mL (94.97 mM) |
| Water | Insoluble |
| Ethanol | 6 mg/mL (6.26 mM) |
| In vivo | 30% Propylene glycol (dissolve first)+5% Tween 80+ddH2O | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 10.44 mL | 52.18 mL | 104.36 mL |
| 0.5 mM | 2.09 mL | 10.44 mL | 20.87 mL |
| 1 mM | 1.04 mL | 5.22 mL | 10.44 mL |
| 5 mM | 0.21 mL | 1.04 mL | 2.09 mL |
*The above data is based on the productmolecular weight 958.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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