生物活性
Gefitinib (Iressa)是一种EGFR抑制剂，可阻断靶细胞中表皮生长因子受体(EGFR)的信号传导。
靶点信息
| Tyr1173 (NR6W cells) | Tyr1173 (NR6wtEGFR cells) | Tyr992 (NR6wtEGFR cells) | Tyr992 (NR6W cells) | |
| 26 nM | 37 nM | 37 nM | 57 nM | |
化学数据
| 目录号 | A10422 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 446.9 |
| Formula | C22H24ClFN4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 184475-35-2 |
| Synonyms | ZD-1839 |
| SMILES | COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4 |
溶解度
| In vitro (25°C) | DMSO | 80 mg/mL (179 mM) |
| Water | Insoluble |
| Ethanol | 4 mg/mL (8.95 mM) |
| In vivo | 1% CMC Na | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 22.38 mL | 111.88 mL | 223.76 mL |
| 0.5 mM | 4.48 mL | 22.38 mL | 44.75 mL |
| 1 mM | 2.24 mL | 11.19 mL | 22.38 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.48 mL |
*The above data is based on the productmolecular weight 446.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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