Background:

UM171 is a selective agonist of human hematopoietic stem cell self-renewal [1].

UM171 is a synthesized analog of UM729, which is screened out for its ability to expand human CD34+ CD45RA– mobilized peripheral blood cells. UM171 was 10- to 20- fold more potent than UM729 with efficacious concentrations of 17 to 19 nM. UM171 treatment enhanced the engraftment potential of CD34+ macaque cells by threefold. It was also found that UM171 had no direct effect on mitosis and no effect on the division rate of phenotypically primitive populations. In addition, UM171 showed cooperation with StemRegenin (SR1) to enhance expansion of short-lived progenitors while UM171 itself selectively enhanced the long-term-HSCs. Moreover, in NSG mice, UM171 exerted effects on lymphoid-deficient differentiation in human hematopoietic reconstitution obtained by transplanting fresh or expanded cells [1].

参考文献:
[1] Fares I, Chagraoui J, Gareau Y, et al. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal. Science, 2014, 345(6203): 1509-1512.