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FPH2(BRD-9424)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FPH2(BRD-9424)图片
CAS NO:957485-64-2
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)353.83
FormulaC14H16ClN5O2S
CAS No.957485-64-2
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 70 mg/mL (197.8 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Other info

Chemical Name: 4-[[[(5-chloro-2-methoxyphenyl)amino]thioxomethyl]amino]-1-ethyl-1H-pyrazole-3-carboxamide

InChi Key: PCHRYHSDDPPZBV-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H16ClN5O2S/c1-3-20-7-10(12(19-20)13(16)21)18-14(23)17-9-6-8(15)4-5-11(9)22-2/h4-7H,3H2,1-2H3,(H2,16,21)(H2,17,18,23)

SMILES Code: O=C(C1=NN(CC)C=C1NC(NC2=CC(Cl)=CC=C2OC)=S)N

Synonyms

FPH2, FPH-2, FPH 2; BRD-9424, BRD9424, BRD 9424

实验参考方法
In Vitro

In vitro activity: FPH2 induces functional proliferation of hepatocytes in vitro, and thus expands mature human primary hepatocytes. FPH2 may lead to the development of new therapeutics for liver diseases.


Cell Assay: FPH2 (BRD-9424) is an inducer of proliferation of primary human hepatocytes. In vitro, FPH2 induced functional proliferation of hepatocytes and might be useful for expanding mature human primary hepatocytes. In human primary hepatocytes, FPH2 increased the number of nuclei undergoing mitosis and hepatocyte nuclei count in a concentration dependent way. Also, FPH2 (40 μM) increased the area of hepatocyte colonies with more hepatocytes and Ki67-positive nuclei, which exhibited hepatocyte nuclear morphologies. In primary human hepatocytes from six additional cell sources, FPH2 increased hepatocytes expansion.

In VivoFPH2 increased hepatocyte at a rate that is consistent with liver regeneration kinetics in vivo
Animal model
Formulation & Dosage
References

Nat Chem Biol. 2013 Aug;9(8):514-20.