生物活性
Imatinib mesylate是一种选择性酪氨酸激酶抑制剂，通过抑制KIT信号转导途径，在治疗胃肠间质瘤中诱导了持续的客观反应。
靶点信息
| PDGFR (Cell-free assay) | c-Kit (M-07e cells) | v-Abl (Cell-free assay) | | |
| 100 nM | 100 nM | 600 nM | | |
化学数据
| 目录号 | A10468 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 589.7 |
| Formula | C29H31N7O.CH4SO3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 220127-57-1 |
| Synonyms | Gleevec, Glivec, CGP-57148B, STI-571 |
| SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O |
溶解度
| In vitro | DMSO | 101 mg/mL (171.26 mM) |
| Water | 101 mg/mL (171.26 mM) |
| Ethanol | Insoluble |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 16.96 mL | 84.79 mL | 169.58 mL |
| 0.5 mM | 3.39 mL | 16.96 mL | 33.92 mL |
| 1 mM | 1.7 mL | 8.48 mL | 16.96 mL |
| 5 mM | 0.34 mL | 1.7 mL | 3.39 mL |
*The above data is based on the productmolecular weight 589.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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