MNI-137 is a selective negative allosteric modulator of group II mGlu receptors (IC50 are 8.3 and 12.6 nM). MNI-137 exhibits no activity at mGlu1, mGlu4, mGlu5 or mGlu8 receptors in a calcium mobilization assay. References: Hemstapat K, Da Costa H, Nong Y, Brady AE, Luo Q, Niswender CM, Tamagnan GD, Conn PJ. A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J Pharmacol Exp Ther. 2007 Jul;322(1):254-64. PubMed PMID: 17416742.

纯度：≥98%

CAS：946619-21-2