生物活性
MLN2238 (Ixazomib)是20S蛋白酶体抑制剂的有效可逆特异性β5位点，IC50值为3.4 nM。
靶点信息
| 20S proteasome (Cell-free assay) | 20S proteasome (Cell-free assay) | | | |
| 0.93 nM(Ki) | 3.4 nM | | | |
化学数据
| 目录号 | A10600 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 361.0 |
| Formula | C14H19BCl2N2O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 1072833-77-2 |
| Synonyms | MLN 2238, MLN-2238 |
| SMILES | B([C@H](CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O |
溶解度
| In vitro (25°C) | DMSO | 64 mg/mL (177.26 mM) |
| Water | Insoluble |
| Ethanol | 8 mg/mL (22.15 mM) |
| In vivo | 5% DMSO+45% PEG 300+ddH2O | 16 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 27.7 mL | 138.5 mL | 277.01 mL |
| 0.5 mM | 5.54 mL | 27.7 mL | 55.4 mL |
| 1 mM | 2.77 mL | 13.85 mL | 27.7 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.54 mL |
*The above data is based on the productmolecular weight 361.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
m.cnreagent.com