BACE1-IN-1是一种有效且具高度脑渗透性的BACE1抑制剂,对人BACE1和BACE2的IC50值分别为32和47nM。
CAS:1310347-50-2
分子式:C18H14F3N5O2
分子量:389.33
纯度:98%
存储:Store at -20°C
Background:
BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively.
[1]. Hilpert H, et al. β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer’s disease. J Med Chem. 2013 May 23;56(10):3980-95.