生物活性
Mycophenolate mofetil (CellCept)是嘌呤生物合成（特别是鸟嘌呤合成）中肌苷单磷酸脱氢酶（IMPDH）的可逆抑制剂，对T细胞和B细胞的生长是必需的。
靶点信息
| Inosine monophosphate dehydrogenase II | Inosine monophosphate dehydrogenase I | | | |
| 27 nM | 39 nM | | | |
化学数据
| 目录号 | A10613 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 433.5 |
| Formula | C23H31NO7 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 128794-94-5 |
| Synonyms | CellCept, RS 61443, TM-MMF |
| SMILES | CC1=C(C(=C(C2=C1COC2=O)O)C/C=C(\C)/CCC(=O)OCCN3CCOCC3)OC |
溶解度
| In vitro (25°C) | DMSO | 77 mg/mL (177.62 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 0.5% methylcellulose | 19 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 23.07 mL | 115.34 mL | 230.68 mL |
| 0.5 mM | 4.61 mL | 23.07 mL | 46.14 mL |
| 1 mM | 2.31 mL | 11.53 mL | 23.07 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.61 mL |
*The above data is based on the productmolecular weight 433.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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