生物活性
Nelarabine是一种嘌呤核苷类似物,可转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸(araGTP),从而抑制DNA合成和细胞毒性,IC50为0.067-2.15 μM。
靶点信息
DNA synthesis (PER-255 cells) | DNA synthesis (HSB2 cells) | DNA synthesis (ALL-SIL cells) | DNA synthesis (JURKAT cells) | |
67 nM | 0.44 μM | 1.24 μM | 2.15 μM | |
化学数据
目录号 | A10632 |
M. Wt | 297.3 |
Formula | C11H15N5O5 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 121032-29-9 |
Synonyms | 506U78 |
SMILES | COC1=NC(=NC2=C1N=CN2[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)N |
溶解度
In vitro (25°C) | DMSO | 55 mg/mL (185.01 mM) |
Water | 3 mg/mL (10.09 mM) |
Ethanol | Insoluble |
In vivo | saline | 2 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 33.64 mL | 168.18 mL | 336.36 mL |
0.5 mM | 6.73 mL | 33.64 mL | 67.27 mL |
1 mM | 3.36 mL | 16.82 mL | 33.64 mL |
5 mM | 0.67 mL | 3.36 mL | 6.73 mL |
*The above data is based on the productmolecular weight 297.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.