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Nelarabine(Arranon)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nelarabine(Arranon)图片
CAS NO:121032-29-9
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
506U78
产品介绍

生物活性

Nelarabine是一种嘌呤核苷类似物,可转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸(araGTP),从而抑制DNA合成和细胞毒性,IC50为0.067-2.15 μM。

靶点信息

DNA synthesis (PER-255 cells)DNA synthesis (HSB2 cells)DNA synthesis (ALL-SIL cells)DNA synthesis (JURKAT cells)
67 nM0.44 μM1.24 μM2.15 μM

化学数据

目录号A10632
M. Wt297.3
FormulaC11H15N5O5
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.121032-29-9
Synonyms506U78
SMILESCOC1=NC(=NC2=C1N=CN2[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)N

溶解度

In vitro (25°C)DMSO55 mg/mL (185.01 mM)
Water3 mg/mL (10.09 mM)
EthanolInsoluble
In vivosaline2 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM33.64 mL168.18 mL336.36 mL
0.5 mM6.73 mL33.64 mL67.27 mL
1 mM3.36 mL16.82 mL33.64 mL
5 mM0.67 mL3.36 mL6.73 mL

*The above data is based on the productmolecular weight 297.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.