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Neratinib(HKI-272)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Neratinib(HKI-272)图片
CAS NO:698387-09-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
100mg电议

产品介绍

生物活性

Neratinib (HKI-272)是一种酪氨酸激酶抑制剂。

Targets

TargetValue
HER2IC50: 59nM
EGFRIC50: 92nM
KDRIC50: 800nM
SrcIC50: 1.4μM
PDK-1IC50: >5μM
IKK2IC50: >9μM
CDK2/CyclinEIC50: >18μM
CDK1/CyclinB1IC50: >18μM
C-Raf/MEK1IC50: >18μM
Tpl-2IC50: >18μM
AktIC50: >20μM
c-MetIC50: >35μM
MK2IC50: >45μM
CDK4/CyclinD1IC50: >50μM

化学数据

目录号A10638
作用机制Inhibitor (抑制剂)
M. Wt557.0
FormulaC30H29ClN6O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.698387-09-6
SMILESCCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)/C=C/CN(C)C

溶解度

In vitro (25°C)DMSOWarmed: 4 mg/mL (7.18 mM)
WaterInsoluble
EthanolInsoluble
In vivo30% PEG400+0.5% Tween80+5% propylene glycol4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM17.95 mL89.77 mL179.53 mL
0.5 mM3.59 mL17.95 mL35.91 mL
1 mM1.8 mL8.98 mL17.95 mL
5 mM0.36 mL1.8 mL3.59 mL

*The above data is based on the productmolecular weight 557.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.