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Nilotinib(AMN-107)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nilotinib(AMN-107)图片
CAS NO:641571-10-0
包装与价格:
包装价格(元)
100mg电议
200mg电议
10mM * 1mL in DMSO电议

产品名称
AMN107
产品介绍

生物活性

Nilotinib (AMN-107)是一种Bcr-Abl抑制剂,IC50小于30 nM。

靶点信息

Bcr-Abl (Murine myeloid progenitor cells)
<30 nM

化学数据

目录号A10644
作用机制Inhibitor (抑制剂)
M. Wt529.5
FormulaC28H22F3N7O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.641571-10-0
SynonymsAMN107
SMILESCC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)N3C=C(N=C3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5

溶解度

In vitro (25°C)DMSO26 mg/mL (49.09 mM)
WaterInsoluble
EthanolInsoluble
In vivo4% DMSO+30% PEG 300+5% Tween 80+ddH2O2 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM18.89 mL94.43 mL188.86 mL
0.5 mM3.78 mL18.89 mL37.77 mL
1 mM1.89 mL9.44 mL18.89 mL
5 mM0.38 mL1.89 mL3.78 mL

*The above data is based on the productmolecular weight 529.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.