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TAE684
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TAE684图片
CAS NO:761439-42-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
NVP-TAE684 , TAE-684
产品介绍

生物活性

TAE684是ALK的抑制剂,也是LRRK2激酶活性的有效抑制剂(针对野生型LRRK2的IC(50)为7.8nM,针对G2019S突变体的为6.1nM)。

靶点信息

ALK (Cell-free assay)
3 nM

化学数据

目录号A10662
作用机制Inhibitor (抑制剂)
M. Wt614.2
FormulaC30H40ClN7O3S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.761439-42-3
SynonymsNVP-TAE684 , TAE-684
SMILESCC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC

溶解度

In vitro (25°C)DMSO3 mg/mL (4.88 mM)
WaterInsoluble
EthanolInsoluble
In vivo30% PEG400+0.5% Tween80+5% propylene glycol, pH 49 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM16.28 mL81.41 mL162.81 mL
0.5 mM3.26 mL16.28 mL32.56 mL
1 mM1.63 mL8.14 mL16.28 mL
5 mM0.33 mL1.63 mL3.26 mL

*The above data is based on the productmolecular weight 614.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.