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Obatoclax mesylate(GX15-070)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Obatoclax mesylate(GX15-070)图片
CAS NO:803712-79-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品介绍

生物活性

Obatoclax Mesylate (GX15-070)是一种Bcl-2拮抗剂,拮抗所有抗凋亡Bcl-2家族蛋白(平均IC50,3 umol/L),包括Mcl-1(IC50,2.9 umol/L)和Bfl-1(IC50,5 umol/L)。

靶点信息

Bcl-2 (Cell-free assay)
0.22 μM(Ki)

化学数据

目录号A10665
作用机制Inhibitor (抑制剂)
M. Wt413.5
FormulaC20H19N3O.CH4O3S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.803712-79-0
SMILESCC1=CC(=C(N1)/C=C/2\C(=C/C(=C\3/C=C4C=CC=CC4=N3)/N2)OC)C.CS(=O)(=O)O

溶解度

In vitro (25°C)DMSO81 mg/mL (195.89 mM)
WaterInsoluble
EthanolInsoluble
In vivo30% PEG400+0.5% Tween80+5% propylene glycol28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM24.18 mL120.92 mL241.84 mL
0.5 mM4.84 mL24.18 mL48.37 mL
1 mM2.42 mL12.09 mL24.18 mL
5 mM0.48 mL2.42 mL4.84 mL

*The above data is based on the productmolecular weight 413.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.