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THZ1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
THZ1图片
CAS NO:1604810-83-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品名称
THZ-1,THZ 1
产品介绍

生物活性

THZ1是一种新型的选择性强效共价CDK7抑制剂,IC50(结合亲和力)为3.2 nM。抑制Jurkat细胞的增殖,IC50为50 nM。

化学数据

目录号A14192
作用机制Inhibitor (抑制剂)
M. Wt566.05
FormulaC31H28ClN7O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1604810-83-4
SynonymsTHZ-1,THZ 1
SMILESCN(C)C/C=C/C(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl

溶解度

In vitro (25°C)DMSO96 mg/mL (150.24 mM)
WaterInsoluble
EthanolInsoluble
In vivo5% DMSO+45% PEG 300+ddH2O3 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM17.67 mL88.33 mL176.66 mL
0.5 mM3.53 mL17.67 mL35.33 mL
1 mM1.77 mL8.83 mL17.67 mL
5 mM0.35 mL1.77 mL3.53 mL

*The above data is based on the productmolecular weight 566.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.