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Parthenolide((-)-Parthenolide)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Parthenolide((-)-Parthenolide)图片
CAS NO:20554-84-1
包装与价格:
包装价格(元)
100mg电议
200mg电议
500mg电议
10mM * 1mL in DMSO电议

产品介绍

生物活性

Parthenolide ((-)-Parthenolide), Nuclear Factor-κB抑制剂,可特异性地耗尽HDAC1蛋白,而不影响其他I/II类 HDACs。促进MDM2的泛素化并激活p53的细胞功能。

靶点信息

HDAC1

化学数据

目录号A10698
作用机制Inhibitor (抑制剂)
M. Wt248.3
FormulaC15H20O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.20554-84-1
SMILESC/C/1=C/CC[C@@]2([C@H](O2)[C@@H]3[C@@H](CC1)C(=C)C(=O)O3)C

溶解度

In vitro (25°C)DMSO49 mg/mL (197.32 mM)
WaterInsoluble
EthanolWarmed: 49 mg/mL (197.32 mM)
In vivo2% DMSO+corn oil9 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM40.27 mL201.37 mL402.74 mL
0.5 mM8.05 mL40.27 mL80.55 mL
1 mM4.03 mL20.14 mL40.27 mL
5 mM0.81 mL4.03 mL8.05 mL

*The above data is based on the productmolecular weight 248.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.