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Pelitinib(EKB-569)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pelitinib(EKB-569)图片
CAS NO:257933-82-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
WAY-EKB 569
产品介绍

生物活性

Pelitinib (EKB-569)是一种有效的,不可逆EGFR抑制剂,IC50为38.5 nM

Targets

TargetValue
EGFRIC50: 38.5nM
SrcIC50: 282nM
MEK/ERKIC50: 800nM
ErbB2IC50: 1.255μM
RafIC50: 3.353μM
c-MetIC50: 4.1μM
CDK4IC50: >20μM

化学数据

目录号A10706
作用机制Inhibitor (抑制剂)
M. Wt467.9
FormulaC24H23ClFN5O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.257933-82-7
SynonymsWAY-EKB 569
SMILESCCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)F)Cl)C#N)NC(=O)/C=C/CN(C)C

溶解度

In vitroDMSO12 mg/mL (25.64 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM21.37 mL106.86 mL213.72 mL
0.5 mM4.27 mL21.37 mL42.74 mL
1 mM2.14 mL10.69 mL21.37 mL
5 mM0.43 mL2.14 mL4.27 mL

*The above data is based on the productmolecular weight 467.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.