PROTACERDegrader-3是合成PAC的中间体。PAC是由抗体通过linker与PROTAC偶联而组成的。PAC的详细信息请参考专利文献WO2017201449A1中的化合物LP2。与PROTAC(无Ab)相比，PAC更加显著降低雌激素受体-α(ERα)水平。
CAS：2158322-29-1
分子式：C71H77N7O12
分子量：1220.41
纯度：98%
存储：Store at -20°C

Background:

PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC comprises an antibody conjugated via a linker to a PROTAC. PAC extracts from patent WO2017201449A1, compound LP2. PAC is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab).

[1]. Thomas Pillow, et al. Protac antibody conjugates and methods of use. WO2017201449A1.