生物活性
STF-62247是一种小分子激动剂,可诱导已经失去von Hippel-Lindau(VHL)肿瘤抑制活性(IC50 = 625 nM)的肾细胞癌(RCC)细胞致死,并自噬。
靶点信息
化学数据
目录号 | A10866 |
作用机制 | Inducer (诱导剂) |
M. Wt | 267.4 |
Formula | C15H13N3S |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 315702-99-9 |
Synonyms | STF62247 |
SMILES | CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3 |
溶解度
In vitro (25°C) | DMSO | 47 mg/mL (175.8 mM) |
Water | Insoluble |
Ethanol | 3 mg/mL (11.22 mM) |
In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 6 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 37.4 mL | 186.99 mL | 373.97 mL |
0.5 mM | 7.48 mL | 37.4 mL | 74.79 mL |
1 mM | 3.74 mL | 18.7 mL | 37.4 mL |
5 mM | 0.75 mL | 3.74 mL | 7.48 mL |
*The above data is based on the productmolecular weight 267.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.