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Vorinostat(SAHA)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vorinostat(SAHA)图片
CAS NO:149647-78-9
包装与价格:
包装价格(元)
200mg电议
500mg电议
10mM * 1mL in DMSO电议

产品名称
Zolinza, MK-0683
产品介绍

生物活性

Vorinostat (SAHA)是HDAC的抑制剂,抑制脱乙酰和导致双方超乙酰化组蛋白和转录因子的积累。

靶点信息

HDAC (Cell-free assay)
~10 nM

化学数据

目录号A10979
作用机制Inhibitor (抑制剂)
M. Wt264.3
FormulaC14H20N2O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.149647-78-9
SynonymsZolinza, MK-0683
SMILESC1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO

溶解度

In vitro (25°C)DMSO49 mg/mL (185.39 mM)
WaterInsoluble
Ethanol3 mg/mL (11.35 mM)
In vivo2% DMSO+30% PEG 300+5% Tween 80+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM37.84 mL189.18 mL378.36 mL
0.5 mM7.57 mL37.84 mL75.67 mL
1 mM3.78 mL18.92 mL37.84 mL
5 mM0.76 mL3.78 mL7.57 mL

*The above data is based on the productmolecular weight 264.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.