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AG-1478(Tyrphostin AG-1478)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AG-1478(Tyrphostin AG-1478)图片
CAS NO:153436-53-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
AG1478, AG 1478
产品介绍

生物活性

AG-1478 (Tyrphostin AG-1478)是EGFR激酶的抑制剂,IC50值为3 nM。

靶点信息

EGFR (Cell-free assay)HER2 (Cell-free assay)PDGFR (Cell-free assay)
3 nM>100 μM>100 μM

化学数据

目录号A11022
作用机制Inhibitor (抑制剂)
M. Wt315.8
FormulaC16H14ClN3O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.153436-53-4
SynonymsAG1478, AG 1478
SMILESCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC

溶解度

In vitro (25°C)DMSO25 mg/mL (79.17 mM)
WaterInsoluble
Ethanol13 mg/mL (41.17 mM)
In vivo15% Captisol28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM31.67 mL158.33 mL316.66 mL
0.5 mM6.33 mL31.67 mL63.33 mL
1 mM3.17 mL15.83 mL31.67 mL
5 mM0.63 mL3.17 mL6.33 mL

*The above data is based on the productmolecular weight 315.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.