生物活性
PF-04691502是PI3K/mTOR激酶抑制剂，也是在PI3K/mTOR信号传导途径中靶向磷脂酰肌醇3激酶（PI3K）和雷帕霉素（mTOR）哺乳动物靶标的药物。
Targets
| Target | Value |
| PI3Kδ | ki: 1.6nM |
| PI3Kα | ki: 1.8nM |
| PI3Kγ | ki: 1.9nM |
| PI3Kβ | ki: 2.1nM |
| P-Akt(S473) | IC50: 3.8nM |
| P-Akt(T308) | IC50: 7.5nM |
| mTOR | ki: 16nM |
化学数据
| 目录号 | A11024 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 425.5 |
| Formula | C22H27N5O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 1013101-36-4 |
| Synonyms | PF04691502 |
| SMILES | CC1=C2C=C(C(=O)N(C2=NC(=N1)N)C3CCC(CC3)OCCO)C4=CN=C(C=C4)OC |
溶解度
| In vitro | DMSO | 13 mg/mL (30.55 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 23.5 mL | 117.51 mL | 235.02 mL |
| 0.5 mM | 4.7 mL | 23.5 mL | 47 mL |
| 1 mM | 2.35 mL | 11.75 mL | 23.5 mL |
| 5 mM | 0.47 mL | 2.35 mL | 4.7 mL |
*The above data is based on the productmolecular weight 425.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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