生物活性
Abiraterone Acetate是Abiraterone的醋酸盐形式，是一种甾体类细胞色素CYP17抑制剂。
靶点信息
| CYP17 (Cell-free assay) | | | | |
| 72 nM | | | | |
化学数据
| 目录号 | A11058 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 391.3 |
| Formula | C26H33NO2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 154229-18-2 |
| Synonyms | CB-7630 |
| SMILES | CC(=O)O[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3CC=C2C1)CC=C4C5=CN=CC=C5)C)C |
溶解度
| In vitro (25°C) | DMSO | Insoluble |
| Water | Insoluble |
| Ethanol | 27 mg/mL |
| In vivo | 5% DMSO+95% Corn oil | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 25.56 mL | 127.78 mL | 255.56 mL |
| 0.5 mM | 5.11 mL | 25.56 mL | 51.11 mL |
| 1 mM | 2.56 mL | 12.78 mL | 25.56 mL |
| 5 mM | 0.51 mL | 2.56 mL | 5.11 mL |
*The above data is based on the productmolecular weight 391.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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