生物活性
ADL5859 HCl是高效的选择性δ阿片受体激动剂，Ki值为0.84 nM，ED50值为20 nM。
靶点信息
| δ-opioid receptor | μ-opioid receptor | κ-opioid receptor | | |
| 0.8 nM(Ki) | 32 nM(Ki) | 37 nM(Ki) | | |
化学数据
| 目录号 | A11072 |
| 作用机制 | Agonist (激动剂) |
| M. Wt | 429 |
| Formula | C24H28N2O3.HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 850173-95-4 |
| Synonyms | ADL-5859 |
| SMILES | CCN(CC)C(=O)C1=CC=C(C=C1)C2=CC3(CCNCC3)OC4=C2C(=CC=C4)O.Cl |
溶解度
| In vitro (25°C) | DMSO | 76 mg/mL (177.17 mM) |
| Water | 4 mg/mL (9.32 mM) |
| Ethanol | 1 mg/mL (2.33 mM) |
| In vivo | 0.5% hydroxyethyl cellulose+0.1% Tween 80 | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 23.31 mL | 116.55 mL | 233.1 mL |
| 0.5 mM | 4.66 mL | 23.31 mL | 46.62 mL |
| 1 mM | 2.33 mL | 11.66 mL | 23.31 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
*The above data is based on the productmolecular weight 429. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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