生物活性
INCB 3284 dimesylate是一种有效的选择性hCCR2拮抗剂，对单核细胞趋化因子分子与hCCR2的结合和趋化活性表现出强烈的拮抗作用。
化学数据
| 目录号 | A11104 |
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 712.8 |
| Formula | C26H31F3N4O4.2CH4O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 887401-93-6 |
| Synonyms | INCB3284, INCB-3284 |
| SMILES | COC1=NC=C(C=C1)C2(CCC(CC2)N3CC[C@H](C3)NC(=O)CNC(=O)C4=CC(=CC=C4)C(F)(F)F)O.CS(=O)(=O)O.CS(=O)(=O)O |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 14.03 mL | 70.15 mL | 140.29 mL |
| 0.5 mM | 2.81 mL | 14.03 mL | 28.06 mL |
| 1 mM | 1.4 mL | 7.01 mL | 14.03 mL |
| 5 mM | 0.28 mL | 1.4 mL | 2.81 mL |
*The above data is based on the productmolecular weight 712.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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