生物活性
PF 431396是一种双粘着斑激酶（FAK）和富含脯氨酸的酪氨酸激酶2（PYK2）抑制剂（IC50值分别为2和11 nM）。
靶点信息
化学数据
| 目录号 | A11142 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 506.5 |
| Formula | C22H21F3N6O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 717906-29-1 |
| Synonyms | PF-431396 |
| SMILES | CN(C1=CC=CC=C1CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C |
溶解度
| In vitro | DMSO | 94 mg/mL (185.58 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 19.74 mL | 98.72 mL | 197.43 mL |
| 0.5 mM | 3.95 mL | 19.74 mL | 39.49 mL |
| 1 mM | 1.97 mL | 9.87 mL | 19.74 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.95 mL |
*The above data is based on the productmolecular weight 506.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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