生物活性
TAK-960是新型的，口服可用的polo样激酶1选择性抑制剂，具有广谱的临床前抗肿瘤活性。
化学数据
| 目录号 | A11146 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 561.6 |
| Formula | C27H34F3N7O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 1137868-52-0 |
| Synonyms | TAK960 |
| SMILES | CN1CCC(CC1)NC(=O)C2=CC(=C(C=C2F)NC3=NC=C4C(=N3)N(CC(C(=O)N4C)(F)F)C5CCCC5)OC |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 17.81 mL | 89.03 mL | 178.06 mL |
| 0.5 mM | 3.56 mL | 17.81 mL | 35.61 mL |
| 1 mM | 1.78 mL | 8.9 mL | 17.81 mL |
| 5 mM | 0.36 mL | 1.78 mL | 3.56 mL |
*The above data is based on the productmolecular weight 561.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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