1-Methyladenine是DNA中烷基化损伤的产物,可以通过氧化去甲基化的损伤逆转来修复。
CAS:5142-22-3
分子式:C6H7N5
分子量:149.15
纯度:98%
存储:Store at -20°C
Background:
1-Methyladenine is a product of alkylation damage in DNA which can be repaired by damage reversal by oxidative demethylation.
[1]. Falnes P?, et al. Repair of 3-methylthymine and 1-methylguanine lesions by bacterial and human AlkB proteins. Nucleic Acids Res. 2004 Dec 1;32(21):6260-7. Print 2004. [2]. Yang H, et al. Effect of 1-methyladenine on double-helical DNA structures. FEBS Lett. 2008 May 14;582(11):1629-33.