生物活性
HA14-1与Bcl-2相互作用，抑制Bcl-2的抗凋亡作用。
靶点信息
化学数据
| 目录号 | A11448 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 409.2 |
| Formula | C17H17BrN2O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 65673-63-4 |
| SMILES | CCOC(=O)C1=C(OC2=C(C1C(C#N)C(=O)OCC)C=C(C=C2)Br)N |
溶解度
| In vitro (25°C) | DMSO | 80 mg/mL (195.48 mM) |
| Water | Insoluble |
| Ethanol | 80 mg/mL (195.48 mM) |
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 24.44 mL | 122.19 mL | 244.38 mL |
| 0.5 mM | 4.89 mL | 24.44 mL | 48.88 mL |
| 1 mM | 2.44 mL | 12.22 mL | 24.44 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.89 mL |
*The above data is based on the productmolecular weight 409.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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