生物活性
Istradefylline (KW-6002)是A2A受体的选择性拮抗剂。
靶点信息
| Adenosine A2A receptor | | | | |
| 2.2 nM(Ki) | | | | |
化学数据
| 目录号 | A11451 |
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 384.4 |
| Formula | C20H24N4O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 155270-99-8 |
| Synonyms | KW-6002,KW6002 |
| SMILES | CCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)/C=C/C3=CC(=C(C=C3)OC)OC)C |
溶解度
| In vitro (25°C) | DMSO | 5 mg/mL (13 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 26.01 mL | 130.07 mL | 260.15 mL |
| 0.5 mM | 5.2 mL | 26.01 mL | 52.03 mL |
| 1 mM | 2.6 mL | 13.01 mL | 26.01 mL |
| 5 mM | 0.52 mL | 2.6 mL | 5.2 mL |
*The above data is based on the productmolecular weight 384.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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