生物活性
INK 128是TORC1/2抑制剂，也是具有潜在抗肿瘤活性的猛禽mTOR（TOR复合物1或TORC1）和raptor-mTOR（TOR复合物2或TORC2）的口服生物利用抑制剂。
Targets
| Target | Value |
| mTOR | ki: 1.4nM |
| mTOR | ki: 1.4nM |
| PI3Kα | IC50: 219nM |
| PI3Kγ | IC50: 221nM |
| PI3Kδ | IC50: 230nM |
| PI3Kβ | IC50: 5293nM |
化学数据
| 目录号 | A11461 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 309.3 |
| Formula | C15H15N7O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 1224844-38-5 |
| Synonyms | INK128, INK-128 |
| SMILES | CC(C)N1C2=C(C(=N1)C3=CC4=C(C=C3)OC(=N4)N)C(=NC=N2)N |
溶解度
| In vitro (25°C) | DMSO | 58 mg/mL (187.5 mM) |
| Water | Insoluble |
| Ethanol | 2 mg/mL (6.46 mM) |
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 32.33 mL | 161.66 mL | 323.31 mL |
| 0.5 mM | 6.47 mL | 32.33 mL | 64.66 mL |
| 1 mM | 3.23 mL | 16.17 mL | 32.33 mL |
| 5 mM | 0.65 mL | 3.23 mL | 6.47 mL |
*The above data is based on the productmolecular weight 309.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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