生物活性
PAP-1 (5-(4-Phenoxybutoxy)psoralen) 是一种有效的，选择性的，口服活性的?Kv1.3?阻滞剂 (EC50=2 nM)。PAP-1 以使用依赖性方式阻止 Kv1.3，并通过优先绑定到通道的 C 型灭活状态来起作用。
化学数据
| 目录号 | A11521 |
| 作用机制 | Blocker (阻断剂) |
| M. Wt | 350.36 |
| Formula | C21H18O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 870653-45-5 |
| SMILES | C1=CC=C(C=C1)OCCCCOC2=C3C=CC(=O)OC3=CC4=C2C=CO4 |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 28.54 mL | 142.71 mL | 285.42 mL |
| 0.5 mM | 5.71 mL | 28.54 mL | 57.08 mL |
| 1 mM | 2.85 mL | 14.27 mL | 28.54 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.71 mL |
*The above data is based on the productmolecular weight 350.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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