生物活性
Tolnaftate 是用作抗真菌剂的合成硫代氨基甲酸酯。据信它以与烯丙胺类似的方式抑制角鲨烯环氧酶，角鲨烯环氧酶是麦角固醇（真菌膜的关键成分）的生物合成途径中的重要酶。
化学数据
| 目录号 | A11657 |
| M. Wt | 307.41 |
| Formula | C19H17NOS |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 2398-96-1 |
| SMILES | CC1=CC(=CC=C1)N(C)C(=S)OC2=CC3=CC=CC=C3C=C2 |
溶解度
| In vitro | DMSO | 56 mg/mL (182.16 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 32.53 mL | 162.65 mL | 325.3 mL |
| 0.5 mM | 6.51 mL | 32.53 mL | 65.06 mL |
| 1 mM | 3.25 mL | 16.26 mL | 32.53 mL |
| 5 mM | 0.65 mL | 3.25 mL | 6.51 mL |
*The above data is based on the productmolecular weight 307.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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