CompoundE是γ-secretase抑制剂。CompoundE抑制β-amyloid(40)，β-amyloid(42)，和Notchγ-分泌酶切割的IC50值分别为0.24，0.37，0.32nM。
CAS：209986-17-4
分子式：C27H24F2N4O3
分子量：490.5
纯度：98%
存储：Store at -20°C

Background:

Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.

Compound E reduces the proliferation of T47D, and MCF-7 cell lines by less than 50% at a concentration of 50 μM[1].

[1]. Beher D, et al. Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology. J Biol Chem. 2001 Nov 30;276(48):45394-402. [2]. Rasul S, et al. Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. Br J Cancer. 2009 Jun 16;100(12):1879-88.