TN-16 is an inhibitor of microtubule polymerization (IC50 = 0.4-1.7 uM).
CAS：33016-12-5
分子式：C19H18N2O2
分子量：306.4
纯度：98%
存储：Store at -20°C

Background:

TN-16 is an inhibitor of microtubule polymerization (IC50 = 0.4-1.7 uM). It blocks taxol-induced assembly of tubulin (IC50 = 6 uM) and blocks colchicine binding to tubulin. Like colchicine, TN-16 inhibits alkylation of tubulin. TN-16 induces metaphase arrest in renal cell carcinoma cells. TN-16 can be used in combination with other inhibitors to enhance the efficiency of human artificial chromosome transfer to recipient cells.