8-Hydroxy-2'-deoxyguanosine is produced by oxidative damage of DNA by reactive oxygen and nitrogen species, including hydroxyl radical and peroxynitrite.
CAS：88847-89-6
分子式：C10H13N5O5
分子量：283.2
纯度：98%
存储：Store at -20°C

Background:

8-Hydroxy-2'-deoxyguanosine is a critical biomarker of oxidative stress and carcinogenesis.

8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a good biomarker for risk assessment of various cancers and degenerative diseases. The biomarker 8-Hydroxy-2'-deoxyguanosine (8-OHdG) or 8-oxodG has been a pivotal marker for measuring the effect of endogenous oxidative damage to DNA and as a factor of initiation and promotion of carcinogenesis. The biomarker has been used to estimate the DNA damage in humans after exposure to cancer-causing agents, such as tobacco smoke, asbestos fibers, heavy metals, and polycyclic aromatic hydrocarbons[1].

参考文献:
[1]. Valavanidis A, et al. 8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Apr;27(2):120-39.