生物活性
Ibutilide fumarate是一种III类抗心律失常药，用于房颤的急性心脏转换和近期发作的心房扑动转为窦性心律。它通过诱导缓慢的内向钠电流发挥抗心律失常作用，延长心肌细胞的动作电位和不应期(生理学)。
化学数据
| 目录号 | A11750 |
| M. Wt | 885.2 |
| Formula | (C20H36N2O3S)2.C4H4O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 122647-32-9 |
| SMILES | CCCCCCCN(CC)CCCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.CCCCCCCN(CC)CCCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.C(=C/C(=O)O)\C(=O)O |
溶解度
| In vitro | DMSO | 88 mg/mL (99.4 mM) |
| Water | 88 mg/mL (99.4 mM) |
| Ethanol | 88 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 11.3 mL | 56.48 mL | 112.97 mL |
| 0.5 mM | 2.26 mL | 11.3 mL | 22.59 mL |
| 1 mM | 1.13 mL | 5.65 mL | 11.3 mL |
| 5 mM | 0.23 mL | 1.13 mL | 2.26 mL |
*The above data is based on the productmolecular weight 885.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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